Mapping the 3D Connectivity of the Rat Inner Retinal Vascular Network Using OCT Angiography.

ABSTRACT:

Purpose

The purpose of this study is to demonstrate three-dimensional (3D) graphing based on optical coherence tomography (OCT) angiography for characterization of the inner retinal vascular architecture and determination of its topologic principles.

Methods

Rat eyes (N = 3) were imaged with a 1300-nm spectral/Fourier domain OCT microscope. A topologic model of the inner retinal vascular network was obtained from OCT angiography data using a combination of automated and manually-guided image processing techniques. Using a resistive network model, with experimentally-quantified flow in major retinal vessels near the optic nerve head as boundary conditions, theoretical changes in the distribution of flow induced by vessel dilations were inferred.

Results

A topologically

SUBMITTER: Leahy C 

PROVIDER: S-EPMC4559217 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature