Genes related to inflammation and bone loss process in periodontitis suggested by bioinformatics methods.

ABSTRACT:

Background

Despite of numerous studies on periodontitis, the mechanism underlying the progression of periodontitis still remains largely unknown. This study aimed to have an expression profiling comparison between periodontitis and normal control and to identify more candidate genes involved in periodontitis and to gain more insights into the molecular mechanisms of periodontitis progression.

Methods

The gene expression profile of GSE16134, comprising 241 gingival tissue specimens and 69 healthy samples as control which were obtained from 120 systemically healthy patients with periodontitis (65 with chronic and 55 with aggressive periodontitis), was downloaded from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) in periodontitis samples were

SUBMITTER: Song L 

PROVIDER: S-EPMC4559289 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature