Prediction model for regional or distant recurrence in endometrial cancer based on classical pathological and immunological parameters.

ABSTRACT:

Background

Adjuvant therapy increases disease-free survival in endometrial cancer (EC), but has no impact on overall survival and negatively influences the quality of life. We investigated the discriminatory power of classical and immunological predictors of recurrence in a cohort of EC patients and confirmed the findings in an independent validation cohort.

Methods

We reanalysed the data from 355 EC patients and tested our findings in an independent validation cohort of 72 patients with EC. Predictors were selected and Harrell's C-index for concordance was used to determine discriminatory power for disease-free survival in the total group and stratified for histological subtype.

Results

Predictors for recurrence were FIGO stage, lymphovascular space invasion and numb

SUBMITTER: Versluis MA 

PROVIDER: S-EPMC4559831 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature