Dataset Information

Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study.

ABSTRACT:

Background

Results from several cohort and case-control studies suggest a protective association between current alcohol intake and risk of thyroid carcinoma, but the epidemiological evidence is not completely consistent and several questions remain unanswered.

Methods

The association between alcohol consumption at recruitment and over the lifetime and risk of differentiated thyroid carcinoma was examined in the European Prospective Investigation into Cancer and Nutrition. Among 477 263 eligible participants (70% women), 556 (90% women) were diagnosed with differentiated thyroid carcinoma over a mean follow-up of 11 years. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using multivariable Cox proportional hazards models.

Results

Compared with participants consuming 0.1-4.9 g of alcohol per day at recruitment, participants consuming 15 or more grams (approximately 1-1.5 drinks) had a 23% lower risk of differentiated thyroid carcinoma (HR=0.77; 95% CI=0.60-0.98). These findings did not differ greatly when analyses were conducted for lifetime alcohol consumption, although the risk estimates were attenuated and not statistically significant anymore. Similar results were observed by type of alcoholic beverage, by differentiated thyroid carcinoma histology or according to age, sex, smoking status, body mass index and diabetes.

Conclusions

Our study provides some support to the hypothesis that moderate alcohol consumption may be associated with a lower risk of papillary and follicular thyroid carcinomas.

SUBMITTER: Sen A

PROVIDER: S-EPMC4559837 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Publications

Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study.

Sen Abhijit A Tsilidis Konstantinos K KK Allen Naomi E NE Rinaldi Sabina S Appleby Paul N PN Almquist Martin M Schmidt Julie A JA Dahm Christina C CC Overvad Kim K Tjønneland Anne A Rostgaard-Hansen Agnetha L AL Clavel-Chapelon Françoise F Baglietto Laura L Boutron-Ruault Marie-Christine MC Kühn Tilman T Katze Verena A VA Boeing Heiner H Trichopoulou Antonia A Tsironis Christos C Lagiou Pagona P Palli Domenico D Pala Valeria V Panico Salvatore S Tumino Rosario R Vineis Paolo P Bueno-de-Mesquita Hb As HA Peeters Petra H PH Hjartåker Anette A Lund Eiliv E Weiderpass Elisabete E Quirós J Ramón JR Agudo Antonio A Sánchez María-José MJ Arriola Larraitz L Gavrila Diana D Gurrea Aurelio Barricarte AB Tosovic Ada A Hennings Joakim J Sandström Maria M Romieu Isabelle I Ferrari Pietro P Zamora-Ros Raul R Khaw Kay-Tee KT Wareham Nicholas J NJ Riboli Elio E Gunter Marc M Franceschi Silvia S

British journal of cancer 20150827 5

<h4>Background</h4>Results from several cohort and case-control studies suggest a protective association between current alcohol intake and risk of thyroid carcinoma, but the epidemiological evidence is not completely consistent and several questions remain unanswered.<h4>Methods</h4>The association between alcohol consumption at recruitment and over the lifetime and risk of differentiated thyroid carcinoma was examined in the European Prospective Investigation into Cancer and Nutrition. Among 4 ...[more]

PMID: 26313664

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Project description:Experimental evidence suggests that alcohol induces cutaneous carcinogenesis, yet epidemiological studies on the link between alcohol intake and skin cancer have been inconsistent. The European Prospective Investigation into Cancer and Nutrition (EPIC) is a prospective cohort initiated in 1992 in 10 European countries. Alcohol intake at baseline and average lifetime alcohol intake were assessed using validated country-specific dietary and lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated in Cox models. A total of 14 037 skin cancer cases (melanoma: n = 2457; basal-cell carcinoma (BCC): n = 8711; squamous-cell carcinoma (SCC): n = 1928; unknown: n = 941) were identified among 450 112 participants (average follow-up: 15 years). Baseline alcohol intake was positively associated with SCC (>15 vs 0.1-4.9 g/day: HR = 1.44, 95% CI = 1.17-1.77; Ptrend = .001), BCC (HR = 1.12, 95% CI = 1.01-1.23; Ptrend = .04), and melanoma risks in men (HR = 1.17, 95% CI = 0.95-1.44; Ptrend = .17), while associations were more modest in women (SCC: HR = 1.09, 95% CI = 0.90-1.30; Ptrend = .13; BCC: HR = 1.08, 95% CI = 1.00-1.17, Ptrend = .03; melanoma: HR = 0.93, 95% CI = 0.80-1.08, Ptrend = .13). Associations were similar for lifetime alcohol intake, with an attenuated linear trend. Lifetime liquor/spirit intake was positively associated with melanoma (fourth vs first quartile: HR = 1.47, 95% CI = 1.08-1.99; Ptrend = .0009) and BCC risks in men (HR = 1.17, 95% CI = 1.04-1.31; Ptrend = .14). Baseline and lifetime intakes of wine were associated with BCC risk (HR = 1.25 in men; HR = 1.11-1.12; in women). No statistically significant associations were found between beverage types and SCC risk. Intake of beer was not associated with skin cancer risk. Our study suggests positive relationships between alcohol intake and skin cancer risk, which may have important implications for the primary prevention of skin cancer.

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Dataset Information

Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study.

Background

Methods

Results

Conclusions

Publications

Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study.

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