Genome-wide detection of intervals of genetic heterogeneity associated with complex traits.

ABSTRACT:

Motivation

Genetic heterogeneity, the fact that several sequence variants give rise to the same phenotype, is a phenomenon that is of the utmost interest in the analysis of complex phenotypes. Current approaches for finding regions in the genome that exhibit genetic heterogeneity suffer from at least one of two shortcomings: (i) they require the definition of an exact interval in the genome that is to be tested for genetic heterogeneity, potentially missing intervals of high relevance, or (ii) they suffer from an enormous multiple hypothesis testing problem due to the large number of potential candidate intervals being tested, which results in either many false positives or a lack of power to detect true intervals.

Results

Here, we present an approach that overcomes both pro

SUBMITTER: Llinares-Lopez F 

PROVIDER: S-EPMC4559912 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature