Cognitive impairment 18 years before clinical diagnosis of Alzheimer disease dementia.

ABSTRACT:

Objective

To examine the relation of performance on brief cognitive tests to development of clinically diagnosed Alzheimer disease (AD) dementia over the following 18 years in a sample of African Americans and European Americans.

Methods

A composite cognitive test score based on tests of episodic memory, executive function, and global cognition was constructed in a prospective population-based sample of 2,125 participants (55% African American and 61% female) aged 65 years and older residing in 4 Chicago neighborhoods. Time before AD dementia diagnosis was categorized into 6 groups corresponding to data collection periods: 0.1-0.9, 1.0-3.9, 4.0-6.9, 7.0-9.9, 10.0-12.9, and 13.0-17.9 years.

Results

Of 2,125 participants without clinical AD dementia, 442 (21%) developed

SUBMITTER: Rajan KB 

PROVIDER: S-EPMC4560057 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature