Anti-DPPX encephalitis: pathogenic effects of antibodies on gut and brain neurons.

ABSTRACT:

Objective

To characterize pathogenic effects of antibodies to dipeptidyl-peptidase-like protein 6 (DPPX), a subunit of Kv4.2 potassium channels, on gut and brain neurons.

Methods

We identified a new patient with anti-DPPX encephalitis and analyzed the effects of the patient's serum and purified immunoglobulin G (IgG), and of serum of a previous patient with anti-DPPX encephalitis, on the activity of enteric neurons by voltage-sensitive dye imaging in guinea pig myenteric and human submucous plexus preparations. We studied the subcellular localization of DPPX by immunocytochemistry in cultured murine hippocampal neurons using sera of 4 patients with anti-DPPX encephalitis. We investigated the influence of anti-DPPX-containing serum and purified IgG on neuronal surface express

SUBMITTER: Piepgras J 

PROVIDER: S-EPMC4560062 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature