Evaluation of aldehyde dehydrogenase 1 promoter polymorphisms identified in human populations.

ABSTRACT:

Background

Cytosolic aldehyde dehydrogenase, or ALDH1A1, functions in ethanol detoxification, metabolism of neurotransmitters, and synthesis of retinoic acid. Because the promoter region of a gene can influence gene expression, the ALDH1A1 promoter regions were studied to identify polymorphism, to assess their functional significance, and to determine whether they were associated with a risk for developing alcoholism.

Methods

Sequence analysis was performed in the promoter region by using Asian, Caucasian, and African American subjects. The resulting polymorphisms were assessed for frequency in Asian, Caucasian, Jewish, and African American populations and tested for associations with alcohol dependence in Asian and African American populations of alcoholics and controls. Th

SUBMITTER: Spence JP 

PROVIDER: S-EPMC4560114 | biostudies-literature | 2003 Sep

REPOSITORIES: biostudies-literature