Loss of TRIM62 expression is an independent adverse prognostic factor in acute myeloid leukemia.

ABSTRACT:

Background

Tripartite motif (TRIM)-62 is a putative tumor suppressor gene whose role in leukemia is unknown.

Materials and methods

We evaluated the effect of TRIM62 protein expression in patients with acute myeloid leukemia (AML). We used reverse-phase protein array methodology to determine TRIM62 levels in leukemia-enriched protein samples from 511 patients newly diagnosed with AML.

Results

TRIM62 levels in AML cells were significantly lower than in normal CD34-positive cells, suggesting that TRIM62 loss might be involved in leukemogenesis, but was not associated with specific karyotypic abnormalities or Nucleophosmin (NPM1), Fms-like Tyrosine Kinase-3 (FLT3), or rat sarcoma viral oncogene (RAS) mutational status. Low TRIM62 levels were associated with shorter comple

SUBMITTER: Quintas-Cardama A 

PROVIDER: S-EPMC4560255 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature