Estrogen- and Satiety State-Dependent Metabolic Lateralization in the Hypothalamus of Female Rats.

ABSTRACT: Hypothalamus is the highest center and the main crossroad of numerous homeostatic regulatory pathways including reproduction and energy metabolism. Previous reports indicate that some of these functions may be driven by the synchronized but distinct functioning of the left and right hypothalamic sides. However, the nature of interplay between the hemispheres with regard to distinct hypothalamic functions is still unclear. Here we investigated the metabolic asymmetry between the left and right hypothalamic sides of ovariectomized female rats by measuring mitochondrial respiration rates, a parameter that reflects the intensity of cell and tissue metabolism. Ovariectomized (saline injected) and ovariectomized+estrogen injected animals were fed ad libitum or fasted to determine 1) the contribu

SUBMITTER: Toth I 

PROVIDER: S-EPMC4560379 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature