Evolution of Intra-specific Regulatory Networks in a Multipartite Bacterial Genome.

ABSTRACT: Reconstruction of the regulatory network is an important step in understanding how organisms control the expression of gene products and therefore phenotypes. Recent studies have pointed out the importance of regulatory network plasticity in bacterial adaptation and evolution. The evolution of such networks within and outside the species boundary is however still obscure. Sinorhizobium meliloti is an ideal species for such study, having three large replicons, many genomes available and a significant knowledge of its transcription factors (TF). Each replicon has a specific functional and evolutionary mark; which might also emerge from the analysis of their regulatory signatures. Here we have studied the plasticity of the regulatory network within and outside the S. meliloti species, looking

SUBMITTER: Galardini M 

PROVIDER: S-EPMC4560400 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature