Plasma Autoantibodies Associated with Basal-like Breast Cancers.

ABSTRACT:

Background

Basal-like breast cancer (BLBC) is a rare aggressive subtype that is less likely to be detected through mammographic screening. Identification of circulating markers associated with BLBC could have promise in detecting and managing this deadly disease.

Methods

Using samples from the Polish Breast Cancer study, a high-quality population-based case-control study of breast cancer, we screened 10,000 antigens on protein arrays using 45 BLBC patients and 45 controls, and identified 748 promising plasma autoantibodies (AAbs) associated with BLBC. ELISA assays of promising markers were performed on a total of 145 BLBC cases and 145 age-matched controls. Sensitivities at 98% specificity were calculated and a BLBC classifier was constructed.

Results

We identified 13

SUBMITTER: Wang J 

PROVIDER: S-EPMC4560641 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature