Gout and the risk of Alzheimer's disease: a population-based, BMI-matched cohort study.

ABSTRACT:

Objective

While gout is associated with cardiovascular (CV)-metabolic comorbidities and their sequelae, the antioxidant effects of uric acid may have neuroprotective benefits. We evaluated the potential impact of incident gout on the risk of developing Alzheimer's disease (AD) in a general population context.

Methods

We conducted an age-matched, sex-matched, entry-time-matched and body mass index (BMI)-matched cohort study using data from The Health Improvement Network, an electronic medical record database representative of the UK general population, from 1 January 1995 to 31 December 2013. Up to five non-gout individuals were matched to each case of incident gout by age, sex, year of enrolment and BMI. We compared incidence rates of AD between the gout and comparison cohor

SUBMITTER: Lu N 

PROVIDER: S-EPMC4560667 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature