Metabolic profiling in Prader-Willi syndrome and nonsyndromic obesity: sex differences and the role of growth hormone.

ABSTRACT:

Objectives

To identify metabolic factors controlling appetite and insulin sensitivity in PWS and assess effects of GH treatment.

Methods

We compared amino acids, fatty acids and acylcarnitines in GH-treated and untreated PWS children and obese and lean controls to identify biomarkers associated with ghrelin, peptide YY and markers of insulin sensitivity (adiponectin and HOMA-IR).

Results

Compared with obese controls (OC), children with PWS had fasting hyperghrelinaemia, hyperadiponectinaemia, hypoinsulinaemia and increased ghrelin/PYY. Hyperghrelinaemia, hyperadiponectinaemia and hypoinsulinaemia were more striking in PWS females than males, and decreases in BCAA were detected only in PWS females. GH-treated PWS subjects had lower leptin and higher IGF-1 and adiponect

SUBMITTER: Irizarry KA 

PROVIDER: S-EPMC4560678 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature