The Secreted Form of Transmembrane Protein 98 Promotes the Differentiation of T Helper 1 Cells.

ABSTRACT: Cytokines mediate the interaction of immune cells. Discovery of novel potential cytokines is of great value for both basic research and clinical application. In this study, we identified a novel immune-related molecule, transmembrane protein 98 (TMEM98), through a high-throughput screening platform for novel potential cytokines at a genome-wide level using the strategy of immunogenomics. So far, there is no characteristic and immune-related functional report about it. In this study, we demonstrate that TMEM98 exists as a type II transmembrane protein both in the ectopically and endogenously expressed systems. Interestingly, TMEM98 could also be secreted through exosomes. Moreover, the native secreted form of TMEM98 could be detected in the supernatants of activated human peripheral blood m

SUBMITTER: Fu W 

PROVIDER: S-EPMC4560856 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature