Prosaposin activates the androgen receptor and potentiates resistance to endocrine treatment in breast cancer.

ABSTRACT:

Introduction

HOX genes play vital roles in growth and development, however, atypical redeployment of these genes is often associated with steroidal adaptability in endocrine cancers. We previously identified HOXC11 to be an indicator of poor response to hormonal therapy in breast cancer. In this study we aimed to elucidate genes regulated by HOXC11 in the endocrine resistant setting.

Methods

RNA-sequencing paired with transcription factor motif-mapping was utilised to identify putative HOXC11 target genes in endocrine resistant breast cancer. Validation and functional evaluation of the target gene, prosaposin (PSAP), was performed in a panel of endocrine sensitive and resistant breast cancer cell lines. The clinical significance of this finding was explored in clinical cohor

SUBMITTER: Ali A 

PROVIDER: S-EPMC4560928 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature