Alternatively spliced tissue factor synergizes with the estrogen receptor pathway in promoting breast cancer progression.

ABSTRACT:

Background

Procoagulant full-length tissue factor (flTF) and its minimally coagulant alternatively spliced isoform (asTF), promote breast cancer (BrCa) progression via different mechanisms. We previously showed that flTF and asTF are expressed by BrCa cells, resulting in autoregulation in a cancer milieu. BrCa cells often express hormone receptors such as the estrogen receptor (ER), leading to the formation of hormone-regulated cell populations.

Objective

To investigate whether TF isoform-specific and ER-dependent pathways interact in BrCa.

Methods

Tissue factor isoform-regulated gene sets were assessed using ingenuity pathway analysis. Tissues from a cohort of BrCa patients were divided into ER-positive and ER-negative groups. Associations between TF isoform levels a

SUBMITTER: Kocaturk B 

PROVIDER: S-EPMC4560996 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature