Heritability, SNP- and Gene-Based Analyses of Cannabis Use Initiation and Age at Onset.

ABSTRACT: Prior searches for genetic variants (GVs) implicated in initiation of cannabis use have been limited to common single nucleotide polymorphisms (SNPs) typed in HapMap samples. Denser SNPs are now available with the completion of the 1000 Genomes and the Genome of the Netherlands projects. More densely distributed SNPs are expected to track the causal variants better. Therefore we extend the search for variants implicated in early stages of cannabis use to previously untagged common and low-frequency variants. We run heritability, SNP and gene-based analyses of initiation and age at onset. This is the first genome-wide study of age at onset to date. Using GCTA and a sample of distantly related individuals from the Netherlands Twin Register, we estimated that the currently measured (and tagge

SUBMITTER: Minica CC 

PROVIDER: S-EPMC4561059 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature