Progenitor cells are mobilized by acute psychological stress but not beta-adrenergic receptor agonist infusion.

ABSTRACT:

Objectives

Stimuli that activate the sympathetic nervous system, such as acute psychological stress, rapidly invoke a robust mobilization of lymphocytes into the circulation. Experimental animal studies suggest that bone marrow-derived progenitor cells (PCs) also mobilize in response to sympathetic stimulation. Here we tested the effects of acute psychological stress and brief pharmacological β-adrenergic (βAR) stimulation on peripheral PC numbers in humans.

Methods

In two studies, we investigated PC mobilization in response to an acute speech task (n=26) and βAR-agonist (isoproterenol) infusion (n=20). A subset of 8 participants also underwent the infusion protocol with concomitant administration of the βAR-antagonist propranolol. Flow cytometry was used to enumerate lympho

SUBMITTER: Riddell NE 

PROVIDER: S-EPMC4561221 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature