Direct MRI detection of impending plaque development in multiple sclerosis.

ABSTRACT:

Objectives

To detect and localize MRI signal changes prior to the parenchymal contrast enhancement that classically defines the radiologic onset of the developing white matter lesion in multiple sclerosis (MS).

Methods

We reviewed 308 high-resolution (≤1 mm(3) voxels) MRI scans at 3T and 7T in 29 patients with active MS. The presence of pre-parenchymal enhancement abnormalities before the appearance of parenchymal enhancement was evaluated in all available scans.

Results

Pre-enhancement signal changes were noted in 26 of 162 enhancing lesions (16%) as linear enhancement of the central vein and/or perivenular hyperintense signal on T2 fluid-attenuated inversion recovery or T2* images. They occur up to 2 months before focal enhancement within the parenchyma in 10% of ca

SUBMITTER: Absinta M 

PROVIDER: S-EPMC4561231 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature