Identification of immunohistochemical markers for distinguishing lung adenocarcinoma from squamous cell carcinoma.

ABSTRACT:

Background

Immunohistochemical staining has been widely used in distinguishing lung adenocarcinoma (LUAD) from lung squamous cell carcinoma (LUSC), which is of vital importance for the diagnosis and treatment of lung cancer. Due to the lack of a comprehensive analysis of different lung cancer subtypes, there may still be undiscovered markers with higher diagnostic accuracy.

Methods

Herein first, we systematically analyzed high-throughput data obtained from The Cancer Genome Atlas (TCGA) database. Combining differently expressed gene screening and receiver operating characteristic (ROC) curve analysis, we attempted to identify the genes which might be suitable as immunohistochemical markers in distinguishing LUAD from LUSC. Then we detected the expression of six of these gene

SUBMITTER: Zhan C 

PROVIDER: S-EPMC4561256 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature