Local and sex-specific biases in crossover vs. noncrossover outcomes at meiotic recombination hot spots in mice.

ABSTRACT: Meiotic recombination initiated by programmed double-strand breaks (DSBs) yields two types of interhomolog recombination products, crossovers and noncrossovers, but what determines whether a DSB will yield a crossover or noncrossover is not understood. In this study, we analyzed the influence of sex and chromosomal location on mammalian recombination outcomes by constructing fine-scale recombination maps in both males and females at two mouse hot spots located in different regions of the same chromosome. These include the most comprehensive maps of recombination hot spots in oocytes to date. One hot spot, located centrally on chromosome 1, behaved similarly in male and female meiosis: Crossovers and noncrossovers formed at comparable levels and ratios in both sexes. In contrast, at a dista

SUBMITTER: de Boer E 

PROVIDER: S-EPMC4561481 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature