Motor pathway degeneration in young ataxia telangiectasia patients: A diffusion tractography study.

ABSTRACT:

Background

Our understanding of the effect of ataxia-telangiectasia mutated gene mutations on brain structure and function is limited. In this study, white matter motor pathway integrity was investigated in ataxia telangiectasia patients using diffusion MRI and probabilistic tractography.

Methods

Diffusion MRI were obtained from 12 patients (age range: 7-22 years, mean: 12 years) and 12 typically developing age matched participants (age range 8-23 years, mean: 13 years). White matter fiber tracking and whole tract statistical analyses were used to assess quantitative fractional anisotropy and mean diffusivity differences along the cortico-ponto-cerebellar, cerebellar-thalamo-cortical, somatosensory and lateral corticospinal tract length in patients using a linear mixed effec

SUBMITTER: Sahama I 

PROVIDER: S-EPMC4561673 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature