Diagnostic prediction models for suspected pulmonary embolism: systematic review and independent external validation in primary care.

ABSTRACT:

Objective

To validate all diagnostic prediction models for ruling out pulmonary embolism that are easily applicable in primary care.

Design

Systematic review followed by independent external validation study to assess transportability of retrieved models to primary care medicine.

Setting

300 general practices in the Netherlands.

Participants

Individual patient dataset of 598 patients with suspected acute pulmonary embolism in primary care.

Main outcome measures

Discriminative ability of all models retrieved by systematic literature search, assessed by calculation and comparison of C statistics. After stratification into groups with high and low probability of pulmonary embolism according to pre-specified model cut-offs combined with qualitative D-dimer t

SUBMITTER: Hendriksen JM 

PROVIDER: S-EPMC4561760 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature