Application of the Wei-Lachin multivariate one-directional test to multiple event-time outcomes.

ABSTRACT:

Background/aims

Cardiovascular outcome trials, among others, aim to assess the beneficial effects of a treatment on multiple event-time outcomes, such as the time to a myocardial infarction and the time to a stroke. The traditional approach is to conduct a simple analysis of a composite outcome defined as the time to the first component event using a logrank test or the Cox Proportional Hazards regression model. This ignores information from other component events after the first. The composite outcome analysis also treats all initial outcome events as equally important, for example, non-fatal myocardial infarction is as important as cardiovascular death.

Methods

Herein, we describe the application of the Wei-Lachin multivariate one-sided (or one-directional) test to the ana

SUBMITTER: Lachin JM 

PROVIDER: S-EPMC4562325 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature