Childhood cognitive ability moderates later-life manifestation of type 2 diabetes genetic risk.

ABSTRACT:

Objective

The study investigated whether childhood cognitive ability moderates Type 2 diabetes polygenic risk manifestation in older age.

Method

In 940 relatively healthy people (mean age 69.55 ± 0.85), we tested whether self-reported diabetes and hemoglobin HbA1c (HbA1c) levels were predicted by diabetes polygenic risk, cognitive ability measured about 60 years earlier, and their interaction. Polygenic risk scores aggregated the small effects of up to nearly 121,000 single-nucleotide polymorphisms (SNPs). Participants' cognitive ability was measured at age 11.

Results

Both polygenic risk and low childhood cognitive ability significantly predicted diabetes diagnosis. Polygenic risk interacted with cognitive ability (p = .02), predicting HbA1c levels more strongly in p

SUBMITTER: Mottus R 

PROVIDER: S-EPMC4562329 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature