Langerhans Cells Maintain Local Tissue Tolerance in a Model of Systemic Autoimmune Disease.

ABSTRACT: Systemic autoimmune diseases such as lupus affect multiple organs, usually in a diverse fashion where only certain organs are affected in individual patients. It is unclear whether the "local" immune cells play a role in regulating tissue specificity in relation to disease heterogeneity in systemic autoimmune diseases. In this study, we used skin as a model to determine the role of tissue-resident dendritic cells (DCs) in local and systemic involvement within a systemic lupus disease model. Skin-resident DCs, namely, Langerhans cells (LCs), have been implicated in regulating tolerance or autoimmunity using elegant transgenic models, however, their role in local versus systemic immune regulation is unknown. We demonstrate that although lymphocytes from skin-draining lymph nodes of autoimmun

SUBMITTER: King JK 

PROVIDER: S-EPMC4562401 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature