Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease.

ABSTRACT:

Introduction

Neuropathologic assessment is the current "gold standard" for evaluating the Alzheimer's disease (AD), but there is no consensus on the methods used.

Methods

Fifteen unstained slides (8 brain regions) from each of the 14 cases were prepared and distributed to 10 different National Institute on Aging AD Centers for application of usual staining and evaluation following recently revised guidelines for AD neuropathologic change.

Results

Current practice used in the AD Centers Program achieved robustly excellent agreement for the severity score for AD neuropathologic change (average weighted κ = .88, 95% confidence interval: 0.77-0.95) and good-to-excellent agreement for the three supporting scores. Some improvement was observed with consensus evaluation but

SUBMITTER: Montine TJ 

PROVIDER: S-EPMC4562409 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature