Angiotensin-(1-7) administration benefits cardiac, renal and progenitor cell function in db/db mice.

ABSTRACT:

Background and purpose

Diabetic patients are at an increased risk of cardiovascular disease, in part due to inflammation and oxidative stress. These two pathological mechanisms also affect other organs and cells including the kidneys and progenitor cells. Angiotensin-(1-7) [Ang-(1-7)] has previously been shown to counterbalance pathological effects of angiotensin II, including inflammation and oxidative stress. The aim of this study was to investigate the effects of short-term (2 weeks) Ang-(1-7) treatment on cardiovascular and renal function in a mouse model of type 2 diabetes (db/db).

Experimental approach

Eight- to nine-week-old db/db mice were administered either vehicle, Ang-(1-7) alone, or Ang-(1-7) combined with an inhibitor (losartan, PD123319, A-779, L-NAME or icati

SUBMITTER: Papinska AM 

PROVIDER: S-EPMC4562506 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature