Activation of EP₄ receptors prevents endotoxin-induced neutrophil infiltration into the airways and enhances microvascular barrier function.

ABSTRACT:

Background and purpose

Pulmonary vascular dysfunction is a key event in acute lung injury. We recently demonstrated that PGE₂ , via activation of E-prostanoid (EP)₄ receptors, strongly enhances microvascular barrier function in vitro. The aim of this study was to investigate the beneficial effects of concomitant EP₄ receptor activation in murine models of acute pulmonary inflammation.

Experimental approach

Pulmonary inflammation in male BALB/c mice was induced by LPS (20 μg per mouse intranasally) or oleic acid (0.15 μL·g^-1 , i.v^. ). In-vitro, endothelial barrier function was determined by measuring electrical impedance.

Key results

PGE₂ activation of EP₄ receptors reduced neutrophil infiltra

SUBMITTER: Konya V 

PROVIDER: S-EPMC4562507 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature