Comparative Analyses of QTLs Influencing Obesity and Metabolic Phenotypes in Pigs and Humans.

ABSTRACT: The pig is a well-known animal model used to investigate genetic and mechanistic aspects of human disease biology. They are particularly useful in the context of obesity and metabolic diseases because other widely used models (e.g. mice) do not completely recapitulate key pathophysiological features associated with these diseases in humans. Therefore, we established a F2 pig resource population (n = 564) designed to elucidate the genetics underlying obesity and metabolic phenotypes. Segregation of obesity traits was ensured by using breeds highly divergent with respect to obesity traits in the parental generation. Several obesity and metabolic phenotypes were recorded (n = 35) from birth to slaughter (242 ± 48 days), including body composition determined at about two months of age (63 ± 10

SUBMITTER: Pant SD 

PROVIDER: S-EPMC4562524 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature