Usefulness of Immunohistochemistry for Microsatellite Instability Screening in Gastric Cancer.

ABSTRACT:

Background/aims

The usefulness of immunohistochemistry to screen for the microsatellite instability (MSI) phenotype in gastric cancer remains unclear. Moreover, the prognostic value of MSI phenotypes in gastric cancer has been debated.

Methods

The clinicopathologic parameters and survival outcomes of 203 MSI-high (MSI-H) and 261 microsatellite-stable (MSS) advanced gastric cancers (AGCs) were compared. Next, we compared the immunohistochemistry results for hMLH1 and hMSH2 with those of a polymerase chain reaction (PCR)-based method. Kaplan-Meier curves and a Cox proportional hazard regression model were used to conduct survival analyses.

Results

The MSI-H AGCs were correlated with older age (p<0.001), female gender (p=0.018), distal location (p<0.001), larger size (p=

SUBMITTER: Bae YS 

PROVIDER: S-EPMC4562780 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature