A pilot study of acupuncture in treating bortezomib-induced peripheral neuropathy in patients with multiple myeloma.

ABSTRACT:

Background

Peripheral neuropathy is the dose limiting toxicity of bortezomib in patients with multiple myeloma (MM).

Objectives

To examine the safety, feasibility and efficacy of acupuncture in reducing bortezomib-induced peripheral neuropathy (BIPN) symptoms.

Methods

Patients with MM experiencing persistent BIPN ≥grade 2 despite adequate medical intervention and discontinuation of bortezomib received 10 acupuncture treatments for 10 weeks (2×/week for 2 weeks, 1×/week for 4 weeks, and then biweekly for 4 weeks). Responses were assessed by the Clinical Total Neuropathy Score (TNSc), Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx) questionnaire, and the Neuropathy Pain Scale (NPS). Repeated-measures analysis of variance w

SUBMITTER: Bao T 

PROVIDER: S-EPMC4562796 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature