Syntheses and studies of new forms of N-sulfonyloxy β-lactams as potential antibacterial agents and β-lactamase inhibitors.

ABSTRACT: The synthesis of a small library of N-sulfonyloxy-2-azetidinones is reported and the preliminary results of the investigation of the biological activity of these molecules are discussed. These new multi-electrophilic β-lactams ('electrophilic bombs') display unexpected selectivity in their antibacterial activity and β-lactamase inhibitory activity.

SUBMITTER: Carosso S 

PROVIDER: S-EPMC4562877 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature