Genome-wide association study of recalcitrant atopic dermatitis in Korean children.

ABSTRACT:

Background

Atopic dermatitis (AD) is a heterogeneous chronic inflammatory skin disease. Most AD during infancy resolves during childhood, but moderate-to-severe AD with allergic sensitization is more likely to persist into adulthood and more often occurs with other allergic diseases.

Objective

We sought to find susceptibility loci by performing the first genome-wide association study (GWAS) of AD in Korean children with recalcitrant AD, which was defined as moderate-to-severe AD with allergic sensitization.

Methods

Our study included 246 children with recalcitrant AD and 551 adult control subjects with a negative history of both allergic disease and allergic sensitization. DNA from these subjects was genotyped; sets of common single nucleotide polymorphisms (SNPs) wer

SUBMITTER: Kim KW 

PROVIDER: S-EPMC4562879 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature