Over-expression of XIST, the Master Gene for X Chromosome Inactivation, in Females With Major Affective Disorders.

ABSTRACT:

Background

Psychiatric disorders are common mental disorders without a pathological biomarker. Classic genetic studies found that an extra X chromosome frequently causes psychiatric symptoms in patients with either Klinefelter syndrome (XXY) or Triple X syndrome (XXX). Over-dosage of some X-linked escapee genes was suggested to cause psychiatric disorders. However, relevance of these rare genetic diseases to the pathogenesis of psychiatric disorders in the general population of psychiatric patients is unknown.

Methods

XIST and several X-linked genes were studied in 36 lymphoblastoid cell lines from healthy females and 60 lymphoblastoid cell lines from female patients with either bipolar disorder or recurrent major depression. XIST and KDM5C expression was also quantified in

SUBMITTER: Ji B 

PROVIDER: S-EPMC4563114 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature