Polymorphisms in Toll-like receptor genes are associated with vitiligo.

ABSTRACT:

Background

The members of Toll-like receptor (TLR) family are responsible for recognizing various molecular patterns associated with pathogens. Their expression is not confined to immune cells and have been detected in skin cells such as keratinocytes and melanocytes. As part of a generated response to pathogens, TLRs are involved in inducing inflammatory mediators to combat these threats. It is therefore not surprising that TLRs have been implicated in inflammatory skin diseases, including atopic dermatitis and psoriasis. Likewise, as key players in autoimmunity, they have been associated with a number of autoimmune diseases. Based on this, the role of TLRs in vitiligo could be suspected, but is yet to be clearly established.

Methods

In order to conduct a genetic associatio

SUBMITTER: Traks T 

PROVIDER: S-EPMC4563240 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature