Bicoid signal extraction with a selection of parametric and nonparametric signal processing techniques.

ABSTRACT: The maternal segmentation coordinate gene bicoid plays a significant role during Drosophila embryogenesis. The gradient of Bicoid, the protein encoded by this gene, determines most aspects of head and thorax development. This paper seeks to explore the applicability of a variety of signal processing techniques at extracting bicoid expression signal, and whether these methods can outperform the current model. We evaluate the use of six different powerful and widely-used models representing both parametric and nonparametric signal processing techniques to determine the most efficient method for signal extraction in bicoid. The results are evaluated using both real and simulated data. Our findings show that the Singular Spectrum Analysis technique proposed in this paper outperforms the synthe

SUBMITTER: Ghodsi Z 

PROVIDER: S-EPMC4563350 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature