Control of regional decidualization in implantation: Role of FoxM1 downstream of Hoxa10 and cyclin D3.

ABSTRACT: Appropriate regulation of regional uterine stromal cell decidualization in implantation, at the mesometrial triangle and secondary decidual zone (SDZ) locations, is critical for successful pregnancy, although the regulatory mechanisms remain poorly understood. In this regard, the available animal models that would specifically allow mechanistic analysis of site-specific decidualization are strikingly limited. Our study found that heightened expression of FoxM1, a Forkhead box transcription factor, is regulated during decidualization, and its conditional deletion in mice reveals failure of implantation with regional decidualization defects such as a much smaller mesometrial decidua with enlarged SDZ. Analysis of cell cycle progression during decidualization both in vivo and in vitro demonst

SUBMITTER: Gao F 

PROVIDER: S-EPMC4563553 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature