A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine.

ABSTRACT: Herein we report the use of bromomaleimides for the construction of stable albumin conjugates via conjugation to its native, single accessible, cysteine followed by hydrolysis. Advantages over the classical maleimide approach are highlighted in terms of quantitative hydrolysis and absence of undesirable retro-Michael deconjugation.

SUBMITTER: Smith ME 

PROVIDER: S-EPMC4563668 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature