DRAM-3 modulates autophagy and promotes cell survival in the absence of glucose.

ABSTRACT: Macroautophagy is a membrane-trafficking process that delivers cytoplasmic constituents to lysosomes for degradation. The process operates under basal conditions as a mechanism to turnover damaged or misfolded proteins and organelles. As a result, it has a major role in preserving cellular integrity and viability. In addition to this basal function, macroautophagy can also be modulated in response to various forms of cellular stress, and the rate and cargoes of macroautophagy can be tailored to facilitate appropriate cellular responses in particular situations. The macroautophagy machinery is regulated by a group of evolutionarily conserved autophagy-related (ATG) proteins and by several other autophagy regulators, which either have tissue-restricted expression or operate in specific conte

SUBMITTER: Mrschtik M 

PROVIDER: S-EPMC4563785 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature