Detection and characterization of small insertion and deletion genetic variants in modern layer chicken genomes.

ABSTRACT:

Background

Small insertions and deletions (InDels) constitute the second most abundant class of genetic variants and have been found to be associated with many traits and diseases. The present study reports on the detection and characterisation of about 883 K high quality InDels from the whole-genome analysis of several modern layer chicken lines from diverse breeds.

Results

To reduce the error rates seen in InDel detection, this study used the consensus set from two InDel-calling packages: SAMtools and Dindel, as well as stringent post-filtering criteria. By analysing sequence data from 163 chickens from 11 commercial and 5 experimental layer lines, this study detected about 883 K high quality consensus InDels with 93% validation rate and an average density of 0.78 InDels/k

SUBMITTER: Boschiero C 

PROVIDER: S-EPMC4563830 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature