Identification of intrinsic imaging phenotypes for breast cancer tumors: preliminary associations with gene expression profiles.

ABSTRACT:

Purpose

To present a method for identifying intrinsic imaging phenotypes in breast cancer tumors and to investigate their association with prognostic gene expression profiles.

Materials and methods

The authors retrospectively analyzed dynamic contrast material-enhanced (DCE) magnetic resonance (MR) images of the breast in 56 women (mean age, 55.6 years; age range, 37-74 years) diagnosed with estrogen receptor-positive breast cancer between 2005 and 2010. The study was approved by the institutional review board and compliant with HIPAA. The requirement to obtain informed consent was waived. Primary tumors were assayed with a validated gene expression assay that provides a score for the likelihood of recurrence. A multiparametric imaging phenotype vector was extracted for each

SUBMITTER: Ashraf AB 

PROVIDER: S-EPMC4564060 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature