The Impact of Selective Dopamine D2, D3 and D4 Ligands on the Rat Gambling Task.

ABSTRACT: Gambling is an addictive disorder with serious societal and personal costs. To-date, there are no approved pharmacological treatments for gambling disorder. Evidence suggests a role for dopamine in gambling disorder and thus may provide a therapeutic target. The present study therefore aimed to investigate the effects of selective antagonists and agonists of D2, D3 and D4 receptors in a rodent analogue of the Iowa gambling task used clinically. In this rat gambling task (rGT), animals are trained to associate different response holes with different magnitudes and probabilities of food pellet rewards and punishing time-out periods. As in the Iowa gambling task, the optimal strategy is to avoid the tempting high-risk high-reward options, and instead favor those linked to smaller per-trial re

SUBMITTER: Di Ciano P 

PROVIDER: S-EPMC4564230 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature