Human cell adhesion molecules: annotated functional subtypes and overrepresentation of addiction-associated genes.

ABSTRACT: Human cell adhesion molecules (CAMs) are essential for proper development, modulation, and maintenance of interactions between cells and cell-to-cell (and matrix-to-cell) communication about these interactions. Despite the differential functional significance of these roles, there have been surprisingly few systematic studies to enumerate the universe of CAMs and identify specific CAMs in distinct functions. In this paper, we update and review the set of human genes likely to encode CAMs with searches of databases, literature reviews, and annotations. We describe likely CAMs and functional subclasses, including CAMs that have a primary function in information exchange (iCAMs), CAMs involved in focal adhesions, CAM gene products that are preferentially involved with stereotyped and morpholo

SUBMITTER: Zhong X 

PROVIDER: S-EPMC4564344 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature