Clinical and Radiologic Disease in Smokers With Normal Spirometry.

ABSTRACT:

Importance

Airflow obstruction on spirometry is universally used to define chronic obstructive pulmonary disease (COPD), and current or former smokers without airflow obstruction may assume that they are disease free.

Objective

To identify clinical and radiologic evidence of smoking-related disease in a cohort of current and former smokers who did not meet spirometric criteria for COPD, for whom we adopted the discarded label of Global Initiative for Obstructive Lung Disease (GOLD) 0.

Design, setting, and participants

Individuals from the Genetic Epidemiology of COPD (COPDGene) cross-sectional observational study completed spirometry, chest computed tomography (CT) scans, a 6-minute walk, and questionnaires. Participants were recruited from local communities at 21 sit

SUBMITTER: Regan EA 

PROVIDER: S-EPMC4564354 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature