Interobserver agreement in dysplasia grading: toward an enhanced gold standard for clinical pathology trials.

ABSTRACT:

Objective

Interobserver agreement in the context of oral epithelial dysplasia (OED) grading has been notoriously unreliable and can impose barriers for developing new molecular markers and diagnostic technologies. This paper aimed to report the details of a 3-stage histopathology review and adjudication process with the goal of achieving a consensus histopathologic diagnosis of each biopsy.

Study design

Two adjacent serial histologic sections of oral lesions from 846 patients were independently scored by 2 different pathologists from a pool of 4. In instances where the original 2 pathologists disagreed, a third, independent adjudicating pathologist conducted a review of both sections. If a majority agreement was not achieved, the third stage involved a face-to-face consensus

SUBMITTER: Speight PM 

PROVIDER: S-EPMC4564355 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature