Importin-α7 Is Involved in the Formation of Ebola Virus Inclusion Bodies but Is Not Essential for Pathogenicity in Mice.
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ABSTRACT:
SUBMITTER: Gabriel G
PROVIDER: S-EPMC4564549 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
Importin-α7 Is Involved in the Formation of Ebola Virus Inclusion Bodies but Is Not Essential for Pathogenicity in Mice.
Gabriel Gülsah G Feldmann Friederike F Reimer Rudolph R Thiele Swantje S Fischer Meike M Hartmann Enno E Bader Michael M Ebihara Hideki H Hoenen Thomas T Feldmann Heinz H
The Journal of infectious diseases 20150716
Ebola virus (EBOV) protein 24 antagonizes the host interferon (IFN) response by hijacking select nuclear importin-α isoforms. Thereby, it blocks STAT1-mediated IFN-α/β and IFN-γ synthesis. However, owing to the lack of importin-α knockout animal models in the past, their role in EBOV pathogenesis remained largely unknown. Here, we demonstrate that importin-α7 is involved in the formation of EBOV inclusion bodies and replication. However, deletion of the gene encoding importin-α7 was not sufficie ...[more]
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