Atypical spatiotemporal signatures of working memory brain processes in autism.

ABSTRACT: Working memory (WM) impairments may contribute to the profound behavioural manifestations in children with autism spectrum disorder (ASD). However, previous behavioural results are discrepant as are the few functional magnetic resonance imaging (fMRI) results collected in adults and adolescents with ASD. Here we investigate the precise temporal dynamics of WM-related brain activity using magnetoencephalography (MEG) in 20 children with ASD and matched controls during an n-back WM task across different load levels (1-back vs 2-back). Although behavioural results were similar between ASD and typically developing (TD) children, the between-group comparison performed on functional brain activity showed atypical WM-related brain processes in children with ASD compared with TD children. These at

SUBMITTER: Urbain CM 

PROVIDER: S-EPMC4564562 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature