A composite peripheral blood gene expression measure as a potential diagnostic biomarker in bipolar disorder.

ABSTRACT: Gene expression in peripheral blood has the potential to inform on pathophysiological mechanisms and has emerged as a viable avenue for the identification of biomarkers. Here, we aimed to identify gene expression candidate genes and to explore the potential for a composite gene expression measure as a diagnostic and state biomarker in bipolar disorder. First, messenger RNA levels of 19 candidate genes were assessed in peripheral blood mononuclear cells of 37 rapid cycling bipolar disorder patients in different affective states (depression, mania and euthymia) during a 6-12-month period and in 40 age- and gender-matched healthy control subjects. Second, a composite gene expression measure was constructed in the first half study sample and independently validated in the second half of the sa

SUBMITTER: Munkholm K 

PROVIDER: S-EPMC4564565 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature